For the 118th Congress, Congresswoman Lesko serves on the prestigious House Committee on Energy and Commerce where she serves as the Vice Chair for the Subcommittee on Oversight and Investigations and on the Subcommittees on Energy, Climate, and Grid Security and Innovation, Data, and Commerce. She also serves as a member of the House Select Subcommittee on the Coronavirus Pandemic.

In the 118th Congress, Congresswoman Lesko was elected to serve as the Region 13 Steering Representative for the Republican Steering Committee, which is tasked with assigning Republican members to the various committees of the House. She was also appointed by House Majority Whip Tom Emmer (R-MN) to serve as a member of the Whip Team.

Lesko founded the Protect Kids Caucus and also serves as a Co-Chair of the Women in STEM Caucus, the Values Action Team, and the Congressional Western Caucus, and also as member of the Republican Study Committee's Steering Committee. Prior to her role in the U.S. House of Representatives, Congresswoman Lesko served in the Arizona Legislature for nine years - the last three of which were in the Arizona Senate. She served as Senate President Pro-Tempore and Chairman of the Senate Appropriations Committee. She was honored by numerous organizations during her time at the Arizona Legislature, including, "Champion of the Taxpayer" "Guardian of Small Business" and "Senator of the Year." Congresswoman Lesko received her Bachelor's degree from the University of Wisconsin. She lives in Peoria with her husband, Joe, and they have three children.