Representing the 16 counties that make up the 3rd Congressional District of Missouri, Blaine is a native of St. Elizabeth, MO where his family has lived for six generations.

Along with his strong agriculture background, Blaine is a small businessman, having been in the banking and insurance industry for over 30 years. He also served as a bank regulator for the state of Missouri earlier in his career.

From 1999 to 2005, Blaine was elected to the Missouri State House of Representatives. During his time in the Legislature, he served as Chairman of the Financial Services Committee and was elected by his colleagues to be the House Republican Caucus Chairman. After leaving office, he was appointed by Governor Matt Blunt to serve as the Director of the Missouri Division of Tourism.

Blaine has represented the 3rd Congressional District of Missouri in the United States House of Representatives since 2009.

In the 118th Congress, Blaine serves on the House Financial Services Committee as Chairman of the Subcommittee on National Security, Illicit Finance, and International Financial Institutions, on the House Select Committee on the Chinese Communist Party, and on the House Small Business Committee.

In the 117th Congress, he served on the House Financial Services Committee as Ranking Member of the Subcommittee on Consumer Protection and as the Ranking Member of the House Committee on Small Business. Blaine is a member of the Knights of Columbus, Eldon Chamber of Commerce, Missouri Farm Bureau, National Rifle Association and a lifelong member of St. Lawrence Catholic Church. He is a graduate of Lincoln University in Jefferson City, MO, where he earned a degree with distinction in political science and a minor in business administration.

Blaine and his wife, Jackie, have three children and seven grandchildren.