In April 2017, Governor Greg Abbott appointed Mano to a six-year term on the board of the Texas Board of Criminal Justice where he serves as the Chair of the Business & Finance Committee and also serves as Trustee of the Windham School District. In July 2020, the United States Trade Representative, Executive Office of the President, appointed Mano to a three-year term as an arbitrator to adjudicate trade disputes under the United States-Mexico-Canada Agreement ("USMCA").

Mano is a past member of the "C" Club of Houston having served on the executive committee from 2012 through 2021 and as President in 2017. He also served as a Trustee of the Houston Region Business Coalition 2020-2021. Mano has also served on the Board of the Hispanic Leadership Alliance since 2012 and as Chairman from 2017 through 2022.

Mano has previously served on Spring Branch Independent School District's Finance and Long-Range Planning committees and as a board member of Heritage Ed, a prospective K-8 charter school serving northwest Houston. With the Spring Branch-Memorial Sports Association (SBMSA), Mano was a longtime youth football coach and has served as a board member from 2012 through 2022 .

In his professional career, Mano is a senior partner of Buck Keenan LLP. For more than a decade, Mano has been recognized as one of the top Texas Lawyers by Texas Super Lawyers and as one of the top lawyers in the US by Best Lawyers in America.

Mano received a BBA (Finance) Degree from the University of Texas (McCombs School of Business) in 1988 and his law degree from Southern Methodist University in 1992.

Mano and his wife of 30 years Melissa reside in west Houston with their three sons, Marcus, Matthew and Mitchell who are all products of Spring Branch ISD.